Reaktion #94870

Reaktionsgleichung

alloxan hydrate

1-Phenylpyrrole

alloxan hydrate

Hydrochloric acid

→

title product

Ausbeute 80.6%

5-Hydroxy-5-(1-phenyl-2-pyrrolyl)-2,4,6-(1H,3H,5H)pyrimidinetrione

Ausbeute 80.6%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturrefluxed for 15 minutes
2. 2
   Temperaturthe acidified mixture refluxed for 15 minutes
3. 3
   SonstigeIncomplete reaction
4. 4
   Temperaturthe mixture refluxed another 15 minutes
5. 5
   Temperaturcooled
6. 6
   Sonstigeevaporated to dryness

Vorschrift

1-Phenylpyrrole (1.4 g., 0.01 mole), alloxan hydrate (1.6 g., 0.01 mole) and 50 ml. of ethanol were combined and refluxed for 15 minutes. No reaction was noted by tlc. 1 N Hydrochloric acid (10 ml., 0.01 mole) was added and the acidified mixture refluxed for 15 minutes. Incomplete reaction was noted by tlc. A second portion of alloxan hydrate (1.6 g., 0.01 mole) was added and the mixture refluxed another 15 minutes, cooled and evaporated to dryness. Trituration of the residue with water gave title product [2.3 g.; m/e 285; m.p. 232°-234° C. (dec); Rf 0.3 (1:1 ethyl acetate:hexane)].

Quelle