Reaktion #94868

Reaktionsgleichung

Alloxan hydrate

1-Methylpyrrole

hydrogen chloride

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title product

Ausbeute 65.0%

5-Hydroxy-5-(1-methyl-2-pyrrolyl)-2,4,6-(1H,3H,5H)pyrimidinetrione

Ausbeute 65.0%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe mixture warmed for 5 minutes on a steam bath
2. 2
   Sonstigethe reaction mixture was evaporated to dryness
3. 3
   Sonstigethe residue triturated with water

Vorschrift

Alloxan hydrate (3.2 g., 0.02 mole) was dissolved in 50 ml. of ethanol by warming. 1-Methylpyrrole (1.6 g., 0.02 mole) was added and the mixture warmed for 5 minutes on a steam bath, while perfusing with hydrogen chloride. After standing at room temperature for 0.5 hour, the reaction mixture was evaporated to dryness and the residue triturated with water to yield title product as a solid [2.9 g.; m/e 223; Rf 0.5 (1:1 ethyl acetate:hexane/5% acetic acid)].

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