Reaktion #94812

Reaktionsgleichung

1-[3-bromo-3-(benzo[b]thien-3-ylcarbonyl)propionyl]-L-proline

acetonitrile

acetonitrile

sodium methoxide

thiobenzoic acid

→

1-[3-(Benzoylthio)-3-(benzo[b]thien-3-ylcarbonyl)propionyl]-L-proline

Lösungsmittel

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe solvent is evaporated in vacuo
2. 2
   SonstigeThe residue is partitioned between dichloromehane and water
3. 3
   workup.ADDITIONcontaining acetic acid
4. 4
   SonstigeThe organic layer is separated
5. 5
   Waschenwashed with water
6. 6
   Trocknendried over magnesium sulfate
7. 7
   SonstigeThe solvent is removed in vacuo
8. 8
   Sonstigeto give the product of the Example as a yellow glass

Vorschrift

As for Example 21, 1-[3-bromo-3-(benzo[b]thien-3-ylcarbonyl)propionyl]-L-proline (0.01 mole) in 25 ml. of acetonitrile is added to a mixture of 0.01 mole of sodium methoxide and 0.015 mole of thiobenzoic acid in 25 ml. of acetonitrile. The mixture is stirred at room temperature for 16 hours, one ml. of acetic acid is added and the solvent is evaporated in vacuo. The residue is partitioned between dichloromehane and water containing acetic acid. The organic layer is separated, washed with water and dried over magnesium sulfate. The solvent is removed in vacuo to give the product of the Example as a yellow glass.

Quelle