Reaktion #94789

ord-bed49674223344e9a7fb86932611280b

Reaktionsgleichung

O=C(c1ccc(Cl)s1)C(Br)CC(=O)N1CCC[C@H]1C(=O)O
1-[3-bromo-3-(5-chloro-2-thenoyl)propionyl]-L-proline
[Na+].[O-]C(=S)c1ccccc1
sodium thiobenzoate
→
O=C(SC(CC(=O)N1CCC[C@H]1C(=O)O)C(=O)c1ccc(Cl)s1)c1ccccc1
1-[3-(Benzoylthio)-3-(5-chloro-2-thenoyl)propionyl]-L-proline

Edukte

O=C(c1ccc(Cl)s1)C(Br)CC(=O)N1CCC[C@H]1C(=O)O
1-[3-bromo-3-(5-chloro-2-thenoyl)propionyl]-L-proline
[Na+].[O-]C(=S)c1ccccc1
sodium thiobenzoate

Reagenzien

Keine

Lösungsmittel

CC#N
acetonitrile

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigeto give the product of the Example as a glass

Vorschrift

As for Example 21, 0.01 mole of 1-[3-bromo-3-(5-chloro-2-thenoyl)propionyl]-L-proline is reacted with sodium thiobenzoate for 16 hours in acetonitrile to give the product of the Example as a glass.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04342690uspto-grants-1982_08