Reaktion #94781

ord-5768a81cf11d44f6b8a060ea1c51f28b

Reaktionsgleichung

O=C(O)CCC(=O)c1cc2ccccc2s1
γ-oxo-benzo[b]thiophene-2-butyric acid
O=C(O)[C@@H]1CCCN1
L-proline
CC([O-])=S.[Na+]
sodium thioacetate
→
CC(=O)SC(CC(=O)N1CCC[C@H]1C(=O)O)C(=O)c1cc2ccccc2s1
1-[3-(Acetylthio)-3-(benzo[b]thien-2-ylcarbonyl)propionyl]-L-proline

Edukte

O=C(O)CCC(=O)c1cc2ccccc2s1
γ-oxo-benzo[b]thiophene-2-butyric acid
O=C(O)[C@@H]1CCCN1
L-proline
CC([O-])=S.[Na+]
sodium thioacetate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigeto give the product of the Example as a glass

Vorschrift

As for Example 4, γ-oxo-benzo[b]thiophene-2-butyric acid is coupled to L-proline. The coupled product is brominated and reacted with sodium thioacetate to give the product of the Example as a glass.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04342690uspto-grants-1982_08