Reaktion #94692

Reaktionsgleichung

2-furyllithium

n-butyllithium

furan

4-chlorobutanol

5-chloropentanol

ammonium chloride

→

4-chloro-1-(2-furyl)-1-butanol

Lösungsmittel

ether

ether

hexane

Reaktionsbedingungen

Aufarbeitung

1. 1
   WaschenThe ether phase is washed with water and brine
2. 2
   Trocknendried over magnesium sulfate and potassium carbonate mixture
3. 3
   Einengenconcentrated
4. 4
   Sonstigeto give a liquid

Vorschrift

To a stirred suspension of 2-furyllithium (prepared from n-butyllithium and furan by the procedure of J. Org. Chem., 27, 1216 (1962) in ether and hexane at -78° C is added a solution of 4-chlorobutanol [Chem. Abstr., 59, 7579F (1963)] in of ether The mixture is warmed to 0° C and treated with saturated ammonium chloride. The ether phase is washed with water and brine, dried over magnesium sulfate and potassium carbonate mixture, and concentrated to give a liquid.

Quelle