Reaktion #94691

Reaktionsgleichung

ethyl mercaptoacetate

4-chloro-1-(2-furyl)-1-butanol

sodium ethoxide

→

4-(carbethoxymethylthio)-1-(2-furyl)-1-butanol

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturTo a stirred, refluxing
2. 2
   Temperaturat reflux for 3 hours
3. 3
   Temperaturcooled
4. 4
   Einengenconcentrated
5. 5
   Sonstigeto remove most of the ethanol
6. 6
   SonstigeThe residue is partitioned with ether and water
7. 7
   WaschenThe ether phase is washed with brine
8. 8
   Trocknendried over potassium carbonate
9. 9
   EinengenThe solution is concentrated
10. 10
    workup.ADDITIONdiluted with xylene
11. 11
    Sonstigeto give an oil

Vorschrift

To a stirred, refluxing mixture of ethyl mercaptoacetate, and 4-chloro-1-(2-furyl)-1-butanol (Example 160), and sodium ethoxide in ethanol. The resulting mixture is stirred at reflux for 3 hours, cooled, and concentrated to remove most of the ethanol. The residue is partitioned with ether and water. The ether phase is washed with brine and dried over potassium carbonate. The solution is concentrated, diluted with xylene, and again conentrated to give an oil.

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