Reaktion #94633

Reaktionsgleichung

2-amino-3-hydroxy-6-methylpyridine

benzoic acid

→

5-methyl-2-phenyloxazolo[4,5-b]pyridine

Lösungsmittel

water

sodium bicarbonate

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONA mixture of 1.25 g
2. 2
   SonstigeThe resulting precipitate was collected
3. 3
   Sonstigerecrystallized from ether

Vorschrift

A mixture of 1.25 g. of 2-amino-3-hydroxy-6-methylpyridine, 6 g. of polyphosphoric acid and 2.0 g. benzoic acid was heated at 190°-200° C. for 10 minutes. The cooled mixture was diluted with water and basified with solid sodium bicarbonate. The resulting precipitate was collected and recrystallized from ether to give 5-methyl-2-phenyloxazolo[4,5-b]pyridine, m.p. 148°-149° C.

Quelle