Reaktion #94631

Reaktionsgleichung

3-hydroxy-6-methylpyridine

nitric acid

→

3-hydroxy-6-methyl-2-nitropyridine

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONof ice cold concentrated sulfuric acid was added 10.9 g
2. 2
   Temperaturto warm to room temperature overnight
3. 3
   workup.STIRRINGwith stirring
4. 4
   Sonstigethe precipitate was collected
5. 5
   Waschenwashed with water
6. 6
   Sonstigedried

Vorschrift

To 40 ml. of ice cold concentrated sulfuric acid was added 10.9 g. of 3-hydroxy-6-methylpyridine. Maintaining the temperature at 6° C., 4.7 ml. of fuming nitric acid was added dropwise with stirring. The mixture was allowed to warm to room temperature overnight. Ice (200 g.) was added with stirring. After the ice had melted, the precipitate was collected, washed with water and dried to give 3-hydroxy-6-methyl-2-nitropyridine, m.p. 103°-105° C.

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