Reaktion #94630

Reaktionsgleichung

2-benzyloxazolo[4,5-b]pyridine

potassium permanganate

sulfuric acid

sodium bisulfite

→

2-benzoyloxazolo[4,5-b]pyridine

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONA mixture of 800 mg
2. 2
   TemperaturAfter cooling
3. 3
   workup.ADDITIONwas added
4. 4
   Sonstigeto remove the manganese dioxide
5. 5
   SonstigeThe crystalline precipitate remaining was collected
6. 6
   Sonstigerecrystallized from ethylacetate

Vorschrift

A mixture of 800 mg. of 2-benzyloxazolo[4,5-b]pyridine, 2.5 g. of potassium permanganate, 35 ml. of water and 6 drops of 2.5 N sodium hydroxide solution was heated at 50°-55° C. for 3 hours. After cooling, sulfuric acid was added to about pH 6 and sufficient sodium bisulfite was added to remove the manganese dioxide. The crystalline precipitate remaining was collected and recrystallized from ethylacetate to give 2-benzoyloxazolo[4,5-b]pyridine, m.p. 151°-153° C.

Quelle