Reaktion #94629

Reaktionsgleichung

2-(3-nitrophenyl)oxazolo[4,5-b]pyridine

→

2-(3-aminophenyl)oxazolo[4,5-b]pyridine

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONA mixture of 700mg
2. 2
   SonstigeThe catalyst was removed by filtration
3. 3
   Einengenthe solvent was concentrated to dryness
4. 4
   SonstigeThe residue was recrystallized from chloroform-petroleum ether

Vorschrift

A mixture of 700mg. of 2-(3-nitrophenyl)oxazolo[4,5-b]pyridine in 50 ml. of ethanol was hydrogenated over 150 mg. of 5% palladium-on-carbon catalyst. The catalyst was removed by filtration and the solvent was concentrated to dryness. The residue was recrystallized from chloroform-petroleum ether to give 2-(3-aminophenyl)oxazolo[4,5-b]pyridine, m.p. 179°-180.5° C.

Quelle