Reaktion #94628

Reaktionsgleichung

2-(2-fluorophenyl)oxazolo[4,5-b]pyridine

2-(2-Fluorophenyl)oxazolo[4,5-b]pyridine

hydrogen peroxide

→

2-(2-fluorophenyl)oxazolo[4,5-b]pyridine-4-oxide

Lösungsmittel

acetic acid

—

ice water

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling the mixture
2. 2
   SonstigeThe precipitate was collected
3. 3
   Sonstigerecrystallized from dioxane-ether

Vorschrift

A solution of 1 g. of 2-(2-fluorophenyl)oxazolo[4,5-b]pyridine (from Example 6) in 10 ml. of acetic acid was treated with 2 ml. of 30% hydrogen peroxide and heated on the steam bath for 16 hours. After cooling the mixture was diluted with ice-water. The precipitate was collected and recrystallized from dioxane-ether to give 2-(2-fluorophenyl)oxazolo[4,5-b]pyridine-4-oxide, m.p. 214°-216° C.

Quelle