Reaktion #94611

Reaktionsgleichung

2-(7-chloro-1,8-naphthyridin-2-yl)-3-phenoxycarbonyloxy-isoindolin-1-one

sec-butylamine

→

2-(7-Chloro-1,8-naphthyridin-2-yl)-3-sec-butylaminocarbonyloxy-isoindolin-1-one

Lösungsmittel

diisopropyl ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe precipitate formed
2. 2
   Filtrationis filtered off
3. 3
   Sonstigerecrystallised from acetonitrile (60 cc.)

Vorschrift

A mixture of 2-(7-chloro-1,8-naphthyridin-2-yl)-3-phenoxycarbonyloxy-isoindolin-1-one (8.6 g.) and sec-butylamine (40 cc.) is heated at 65° C. until dissolution. The reaction mixture is then diluted with diisopropyl ether (240 cc.). The precipitate formed is filtered off and recrystallised from acetonitrile (60 cc.). 2-(7-Chloro-1,8-naphthyridin-2-yl)-3-sec-butylaminocarbonyloxy-isoindolin-1-one (3 g.), melting at 220°-222° C., is thus obtained.

Quelle