Reaktion #94593

Reaktionsgleichung

ethyl 4-methyl-2-piperidinecarboxylate

N2 (2-phenoxathiinylsulfonyl)-L-arginyl chloride hydrochloride

→

ethyl 1-[N2 -(2-phenoxathiinylsulfonyl)-L-arginyl]-4-methyl-2-piperidinecarboxylate

Lösungsmittel

chloroform

chloroform

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeobtained above
2. 2
   Waschenthe chloroform solution was washed twice with 25 ml of saturated sodium chloride solution
3. 3
   Trocknendried over Na2SO4
4. 4
   Sonstigeevaporated in vacuo
5. 5
   WaschenThe oily residue was washed with ether

Vorschrift

To a stirred solution of 3.6 g of ethyl 4-methyl-2-piperidinecarboxylate in 50 ml of chloroform, which was cooled in an ice-salt bath, was added in portions N2 -(2-phenoxathiinylsulfonyl)-L-arginyl chloride hydrochloride obtained above. The reaction mixture was stirred overnight at room temperature. At the end of this period, 50ml of chloroform was added and the chloroform solution was washed twice with 25 ml of saturated sodium chloride solution, dried over Na2SO4 and evaporated in vacuo. The oily residue was washed with ether to give 3.5 g of powdery ethyl 1-[N2 -(2-phenoxathiinylsulfonyl)-L-arginyl]-4-methyl-2-piperidinecarboxylate.

Quelle