Reaktion #94592

ord-230cf04c0f214fd6b4278fd6736d9fdd

Reaktionsgleichung

N#N.N=C(N)NCCC[C@H](NS(=O)(=O)c1ccc2c(c1)Sc1ccccc1O2)C(=O)O
N2 (2-phenoxathiinylsulfonyl)-L-arginine
O=S(Cl)Cl
thionyl chloride
CCOCC
diethyl ether
→
Cl.N#N.N=C(N)NCCC[C@H](NS(=O)(=O)c1ccc2c(c1)Sc1ccccc1O2)C(=O)Cl
N2 (2-phenoxathiinylsulfonyl)-L-arginyl chloride hydrochloride

Edukte

N#N.N=C(N)NCCC[C@H](NS(=O)(=O)c1ccc2c(c1)Sc1ccccc1O2)C(=O)O
N2 (2-phenoxathiinylsulfonyl)-L-arginine
O=S(Cl)Cl
thionyl chloride
CCOCC
diethyl ether

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigeresulted in a precipitate which
  2. 2
    Filtrationwas collected by filtration
  3. 3
    Waschenwashed several times with dry diethyl ether

Vorschrift

A suspension of 3 g of N2 -(2-phenoxathiinylsulfonyl)-L-arginine in 20 ml of thionyl chloride was stirred for 2 hours at room temperature. Addition of cold dry diethyl ether resulted in a precipitate which was collected by filtration and washed several times with dry diethyl ether to give N2 -(2-phenoxathiinylsulfonyl)-L-arginyl chloride hydrochloride.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04131673uspto-grants-1978_12