Reaktion #94555

Reaktionsgleichung

1-p-chlorophenyl-3-azabicyclo[3.1.0]hexane

sodium carbonate

p-chlorobenzoyl chloride

→

3-p-chlorobenzoyl-1-(p-chlorophenyl)-3-azabicyclo[3.1.0]hexane

Lösungsmittel

benzene

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe benzene is evaporated
2. 2
   workup.DISSOLUTIONthe dark purple residue is dissolved in 200 ml of chloroform
3. 3
   Waschenwashed successively with 5% sodium carbonate, 0.5N hydrochloric acid
4. 4
   Trocknenwith water and dried over sodium sulfate giving a dark purple oil
5. 5
   workup.ADDITIONAddition of ether

Vorschrift

A 19.35 g sample of 1-p-chlorophenyl-3-azabicyclo[3.1.0]hexane, 10.59 g of sodium carbonate and 17.5 g of p-chlorobenzoyl chloride are reacted in benzene. The benzene is evaporated and the dark purple residue is dissolved in 200 ml of chloroform and washed successively with 5% sodium carbonate, 0.5N hydrochloric acid and then with water and dried over sodium sulfate giving a dark purple oil. Addition of ether gives the product 3-p-chlorobenzoyl-1-(p-chlorophenyl)-3-azabicyclo[3.1.0]hexane as grey crystals, mp 98°-100° C.

Quelle