Reaktion #945300

ord-e2c59a665ffd4743932b2796e9f6f56f

Reaktionsgleichung

CCCCn1c(=O)n(Cc2ccccc2F)c(=O)c2[nH]c(Cc3ccc(N)cc3)nc21
8-(4-amino-benzyl)-3-butyl-1-(2-fluoro-benzyl)-3,7-dihydro-purine-2,6-dione
O=S(=O)(Cl)c1ccc(Cl)c(Cl)c1
3,4-dichloro-benzenesulfonyl chloride
→
CCCCn1c(=O)n(Cc2ccccc2F)c(=O)c2[nH]c(Cc3ccc(NS(=O)(=O)c4ccc(Cl)c(Cl)c4)cc3)nc21
N-{4-[3-Butyl-1-(2-fluoro-benzyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-ylmethyl]-phenyl}-3,4-dichloro-benzenesulfonamide

Edukte

CCCCn1c(=O)n(Cc2ccccc2F)c(=O)c2[nH]c(Cc3ccc(N)cc3)nc21
8-(4-amino-benzyl)-3-butyl-1-(2-fluoro-benzyl)-3,7-dihydro-purine-2,6-dione
O=S(=O)(Cl)c1ccc(Cl)c(Cl)c1
3,4-dichloro-benzenesulfonyl chloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Prepared from 8-(4-amino-benzyl)-3-butyl-1-(2-fluoro-benzyl)-3,7-dihydro-purine-2,6-dione and 3,4-dichloro-benzenesulfonyl chloride. Purity (ELSD, based on MW=630.5)=100%.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07148229B2uspto-grants-2006_12