Reaktion #945

Reaktionsgleichung

benzaldehyde

product

Ethyl 2-aminobutyrate hydrochloride

magnesium sulphate

triethylamine

→

desired product

Ausbeute 88.9%

Ethyl 2-benzylideneaminobutyrate

Ausbeute 88.9%

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationthen filtered
2. 2
   EinengenThe filtrate was concentrated
3. 3
   Sonstigetriturated in diethyl ether
4. 4
   Filtrationfiltered
5. 5
   Einengenconcentrated

Vorschrift

A solution of the product from step (a) (149.6 g), magnesium sulphate (74.3 g), and triethylamine (246 ml) in dichloromethane (1500 ml) was stirred at room temperature under nitrogen and benzaldehyde (94.9 g, Aldrich) was added dropwise. The mixture was stirred at room temperature for 3 hours then filtered. The filtrate was concentrated, triturated in diethyl ether, filtered and concentrated to yield the desired product as a yellow oil (174 g). 1H NMR consistent with the proposed structure.

Quelle