Reaktion #9447

Reaktionsgleichung

7-Bromo-2-butyl-1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine

benzeneboronic acid

→

2-butyl-1-isobutyl-7-phenyl-1H-imidazo[4,5-c]quinolin-4-amine

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigePurification by chromatography on silica gel (20% acetone in toluene to 60% acetone in toluene gradient)

Vorschrift

7-Bromo-2-butyl-1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine and benzeneboronic acid were coupled according to the general procedure described in Part J of Example 1. Purification by chromatography on silica gel (20% acetone in toluene to 60% acetone in toluene gradient) afforded 2-butyl-1-isobutyl-7-phenyl-1H-imidazo[4,5-c]quinolin-4-amine as a white solid, m.p. >250° C.

Quelle