Reaktion #943989

Reaktionsgleichung

water

7-hydroxy-6-methoxy-1-tetralone

benzyl bromide

K2CO3

→

product

Ausbeute 62.8%

7-Benzyloxy-6-methoxy-3,4-dihydro-2H-naphthalen-1-one

Ausbeute 62.8%

Lösungsmittel

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   Temperaturto reflux overnight
3. 3
   SonstigeThe reaction
4. 4
   Temperaturas cooled
5. 5
   Extraktionextracted with EtOAc
6. 6
   TrocknenThe EtOAc was dried over Na2SO4
7. 7
   Sonstigeevaporated
8. 8
   Sonstigeto give 7 g of crude product
9. 9
   SonstigeCrystallization with Et2O

Vorschrift

A mixture of 4.5 g (0.0233 mole) of 7-hydroxy-6-methoxy-1-tetralone, 5.4 g (0.032 mole) of benzyl bromide and 10 g (0.072 mole) of K2CO3 in 150 ml of acetone was heated to reflux overnight. The reaction as cooled, poured into water and extracted with EtOAc. The EtOAc was dried over Na2SO4 and evaporated to give 7 g of crude product. Crystallization with Et2O gave 4.13 g of product as a white solid, mp 110-111° C.

Quelle