Reaktion #942974

Reaktionsgleichung

4-methoxy-2-methylphenylamine

dimethylethylamine

acetic anhydride

→

colorless crystals

Ausbeute 75.0%

N-(4-Methoxy-2-methylphenyl)acetamide

Ausbeute 75.0%

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe solution heated
2. 2
   workup.STIRRINGIt was stirred at room temperature for 1 hour
3. 3
   FiltrationThe resulting precipitate was filtered off with suction
4. 4
   Waschenwashed several times with a little cold tetrahydrofuran
5. 5
   Sonstigedried

Vorschrift

41.1 g (0.3 mol) of 4-methoxy-2-methylphenylamine and 37 g (0.5 mol) of dimethylethylamine were dissolved in 50 ml of tetrahydrofuran, and 35.7 g (0.35 mol) of acetic anhydride were added while stirring. The solution heated to boiling during this. It was stirred at room temperature for 1 hour and cooled to 0° C. The resulting precipitate was filtered off with suction and washed several times with a little cold tetrahydrofuran and dried. 40 g (75%) of colorless crystals of the desired product were obtained.

Quelle