Reaktion #94294

Reaktionsgleichung

2-(4-methoxyphenyl)imidazo[1,2-a]pyridine

methyl iodide

methyl iodide

→

1-methyl-2-(4-methoxyphenyl)imidazo[1,2-a]pyridinium iodide

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturrefluxed for 3 hrs
2. 2
   Temperaturreflux
3. 3
   SonstigeThe solids which precipitate
4. 4
   Temperaturon cooling
5. 5
   Filtrationare filtered
6. 6
   workup.DISSOLUTIONpartially dissolved
7. 7
   Filtrationfiltered
8. 8
   TemperaturThe isopropanol filtrate is cooled
9. 9
   workup.ADDITIONtreated with diethyl ether
10. 10
    FiltrationThe crystallized product is filtered
11. 11
    Sonstigedried
12. 12
    Sonstigeto give 1.03 g

Vorschrift

To 2.23 g. of 2-(4-methoxyphenyl)imidazo[1,2-a]pyridine in 50 ml. of acetonitrile is added 2.84 g. of methyl iodide, and the resulting reaction mixture refluxed for 3 hrs. Additional methyl iodide (2 ml.) is added and reflux continued for one hour. The solids which precipitate on cooling are filtered and partially dissolved in boiling isopropanol and filtered. The isopropanol filtrate is cooled and treated with diethyl ether. The crystallized product is filtered and dried to give 1.03 g., m.p. 194-196° C.

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