Reaktion #94270

Reaktionsgleichung

4-chloro-2-methyl-6-phenyl-2H-pyrazolo[3,4-b]pyridine

sodium

ethanol

→

4-Ethoxy-2-methyl-6-phenyl-2H-pyrazolo[3,4-b]pyridine

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture is heated at 150° in an autoclave for 5 hours
2. 2
   TemperaturAfter cooling
3. 3
   Filtrationthe crystallized 4-ethoxy-2-methyl-6-phenyl2H-pyrazolo[3,4-b]pyridine is filtered off
4. 4
   Waschenwashed with alcohol
5. 5
   Sonstigeis obtained by evaporation of the mother liquor, total yield: 8.6 g
6. 6
   SonstigeRecrystallization from ethanol
7. 7
   Sonstigegives a product of the melting point 171°-172°

Vorschrift

8.5 g. of 4-chloro-2-methyl-6-phenyl-2H-pyrazolo[3,4-b]pyridine (0.035 mol.) are added to a solution of 0.9 g. of sodium (0.038 mol.) in 100 ml. of absolute ethanol. The mixture is heated at 150° in an autoclave for 5 hours. After cooling, the crystallized 4-ethoxy-2-methyl-6-phenyl2H-pyrazolo[3,4-b]pyridine is filtered off, washed with alcohol and then with water, yield: 6.2 g.; m.p. 170°-171°. An additional crop of 2.4 g. is obtained by evaporation of the mother liquor, total yield: 8.6 g. (97%). Recrystallization from ethanol gives a product of the melting point 171°-172°.

Quelle