Reaktion #94262

ord-f8dbab36413743239e99b6ff6274a760

Reaktionsgleichung

O=C(Cl)c1nnnn1Cc1ccccc1
1-benzyl-1H-tetrazole-5-carbonyl chloride
CN1CCN(c2cccc(N)c2C#N)CC1
2-amino-6-(4-methyl-1-piperazinyl)benzonitrile
→
CN1CCN(c2cccc(NC(=O)c3nnnn3Cc3ccccc3)c2C#N)CC1
1-benzyl-N-[2-cyano-3-(4-methyl-1-piperazinyl)phenyl]-1H-tetrazole-5-carboxamide

Edukte

O=C(Cl)c1nnnn1Cc1ccccc1
1-benzyl-1H-tetrazole-5-carbonyl chloride
CN1CCN(c2cccc(N)c2C#N)CC1
2-amino-6-(4-methyl-1-piperazinyl)benzonitrile

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

In a manner similar to Example I, 1-benzyl-1H-tetrazole-5-carbonyl chloride is condensed with 2-amino-6-(4-methyl-1-piperazinyl)benzonitrile to give 1-benzyl-N-[2-cyano-3-(4-methyl-1-piperazinyl)phenyl]-1H-tetrazole-5-carboxamide.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04129735uspto-grants-1978_12