Reaktion #94238

Reaktionsgleichung

4-hydroxy-4-phenylpiperidine

carbon dioxide

2-(1,4-benzodioxan-2-yl)-acetic acid

→

1-[2-(1,4-benzodioxan-2-yl)-acetyl]-4-hydroxy-4-phenylpiperidine

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeIt is evaporated
2. 2
   Waschenthe solution washed with water, N hydrochloric acid and water
3. 3
   Sonstigedried
4. 4
   Sonstigeevaporated

Vorschrift

To the stirred solution of 11.64 g of 2-(1,4-benzodioxan-2-yl)-acetic acid in 60 ml of tetrahydrofuran is added 12 g of 1,1-carbonyldiimidazole. After the evolution of carbon dioxide has ceased, 10.6 g of 4-hydroxy-4-phenylpiperidine are added and the mixture stirred overnight at room temperature. It is evaporated, the residue taken up in ethyl acetate, the solution washed with water, N hydrochloric acid and water, dried and evaporated, to yield the 1-[2-(1,4-benzodioxan-2-yl)-acetyl]-4-hydroxy-4-phenylpiperidine.

Quelle