Reaktion #94213

Reaktionsgleichung

bromine

HBr

5-chloro-6-n-propylsulfamoyl-1-indanone

→

2-Bromo-5-chloro-6-n-propylsulfamoyl-1-indanone

Lösungsmittel

ethyl acetate

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenthe solution is concentrated to dryness, and 50 ml of water
2. 2
   workup.ADDITIONare added to the residue
3. 3
   FiltrationThe crystalline precipitate is filtered off with suction
4. 4
   Waschenwashed with water

Vorschrift

0.5 L Milliliter of 48% aqueous HBr is added to a solution of 5.76 g (20 mmoles) of 5-chloro-6-n-propylsulfamoyl-1-indanone in 50 ml of ethyl acetate. Thereafter a solution of 3.20 g (20 mmoles) of bromine in 20 ml of ethyl acetate is added dropwise. The mixture is stirred for 1 hour at room temperature, then the solution is concentrated to dryness, and 50 ml of water are added to the residue. The crystalline precipitate is filtered off with suction and washed with water. 2-Bromo-5-chloro-6-n-propylsulfamoyl-1-indanone is obtained which has a melting point of from 150° to 154° C.

Quelle