Reaktion #94210

Reaktionsgleichung

5-chloro-6-chlorosulfonyl-1-indanone

ammonia

→

5-Chloro-6-sulfamoyl-1-indanone

Lösungsmittel

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto evaporate
2. 2
   workup.DISSOLUTIONthe residue is dissolved in water
3. 3
   Temperaturis heated within a short time on the water-bath
4. 4
   Filtrationis filtered
5. 5
   workup.ADDITIONafter the addition of active charcoal
6. 6
   Filtrationthe precipitate is filtered off with suction
7. 7
   Waschenis washed with water
8. 8
   Sonstigeis in the range of from 205° to 208° C.
9. 9
   Sonstigeafter recrystallization
10. 10
    workup.ADDITIONfrom a mixture of acetone and water it
11. 11
    Sonstigeis 216° to 218° C.

Vorschrift

99.6 Grams of 5-chloro-6-chlorosulfonyl-1-indanone are introduced portionwise into 700 ml of liquid ammonia. The solvent is allowed to evaporate and the residue is dissolved in water, is heated within a short time on the water-bath and is filtered after the addition of active charcoal. The solution is acidified with hydrochloric acid to a pH of 2, the precipitate is filtered off with suction and is washed with water. The melting point of 5-chloro-6-sulfamoyl-1-indanone is in the range of from 205° to 208° C., and after recrystallization from a mixture of acetone and water it is 216° to 218° C.

Quelle