Reaktion #94209

Reaktionsgleichung

hydrochloric acid

5-chloro-6-nitro-1-indanone

→

5-Chloro-6-amino-1-indanone

Lösungsmittel

ethanol

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe precipitate is filtered off with suction
2. 2
   Sonstigethe product is precipitated from the hot filtrate by the addition of water
3. 3
   Filtrationsuction-filtered
4. 4
   Waschenwashed with water
5. 5
   Trocknenthe filtrate is dried with Na2SO4
6. 6
   Einengenis then concentrated to dryness
7. 7
   Sonstigeafter which process a further amount of the product is obtained
8. 8
   Sonstigemelts at a temperature of from 198° to 200° C.
9. 9
   Sonstigeis in the range of from 203° to 205° C.

Vorschrift

114 Grams (2.01 moles) of iron powder are added to a solution of 134 g (0.64 mole) of 5-chloro-6-nitro-1-indanone in 1600 ml of ethanol, then 63.5 ml of concentrated hydrochloric acid are added dropwise, and the reaction mixture is boiled for 4 hours. The precipitate is filtered off with suction, and the product is precipitated from the hot filtrate by the addition of water, then suction-filtered and washed with water. The residue of the reaction mixture is boiled with chloroform, the filtrate is dried with Na2SO4 and is then concentrated to dryness, after which process a further amount of the product is obtained. The substance melts at a temperature of from 198° to 200° C., and after recyrstallization from ethanol the melting point is in the range of from 203° to 205° C.

Quelle