Reaktion #94197

Reaktionsgleichung

ethyl bromopyruvate

4-methylquinazoline

→

product

2-Carbethoxy-1H-pyrrolo[1,2-c]quinazolin-4-ium bromide

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturat reflux for 16 hours during which time a yellow precipitate
2. 2
   Sonstigeformed
3. 3
   TemperaturThe reaction mixture was cooled
4. 4
   Filtrationthe solid filtered
5. 5
   Sonstigedried
6. 6
   Sonstigeto yield crude product
7. 7
   SonstigeCrystallization from MeOH

Vorschrift

A solution of ethyl bromopyruvate (32.76 g, 0.172 m) and 4-methylquinazoline (15.61g, 0.109 m) in dry ethanol (400 ml) was heated at reflux for 16 hours during which time a yellow precipitate formed. The reaction mixture was cooled and the solid filtered and dried to yield crude product. Crystallization from MeOH afforded the product as a yellow solid; m.p. 274°-275° C.

Quelle