Reaktion #941529

Reaktionsgleichung

4-methylpyrimidine

para-formaldehyde

→

title compound

4-(2-Hydroxyethyl)pyrimidine

Lösungsmittel

ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigesealed capacity pressure vessel at 165° C. for 3.5 hours
2. 2
   TemperaturAfter cooling
3. 3
   Sonstigethe solvents evaporated
4. 4
   Sonstigeto afford an oil
5. 5
   SonstigeThis was purified by silica column chromatography
6. 6
   Wascheneluting with dichloromethane
7. 7
   SonstigeThe ethyl acetate fractions were evaporated

Vorschrift

A mixture of 4-methylpyrimidine (10 g, 106 mmol) and para-formaldehyde (3 g) was stirred in a 50 mL sealed capacity pressure vessel at 165° C. for 3.5 hours. After cooling, ether was added and the solvents evaporated to afford an oil. This was purified by silica column chromatography using a Flashmaster system, eluting with dichloromethane, then chloroform, ether, and finally ethyl acetate. The ethyl acetate fractions were evaporated to afford the title compound as an oil.

Quelle