Reaktion #94144

ord-ac015ac2fa374596aed66c2d2775f103

Reaktionsgleichung

COc1ccc(COC(=O)NCCCC(CSC(C)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)cc1
Nα -[2-acetylthiomethyl-5-(p-methoxybenzyloxycarbonylamino)pentanoyl]-L-arginine
O=C(O)C(F)(F)F
trifluoroacetic acid
→
CC(=O)SCC(CCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O.O=C(O)C(F)(F)F
Nα -(2-acetylthiomethyl-5-aminopentanoyl)-L-arginine trifluoroacetate

Edukte

COc1ccc(COC(=O)NCCCC(CSC(C)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)cc1
Nα -[2-acetylthiomethyl-5-(p-methoxybenzyloxycarbonylamino)pentanoyl]-L-arginine
O=C(O)C(F)(F)F
trifluoroacetic acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Einengenconcentrated to dryness in vacuo

Vorschrift

A solution of Nα -[2-acetylthiomethyl-5-(p-methoxybenzyloxycarbonylamino)pentanoyl]-L-arginine (1 g) in trifluoroacetic acid (10 ml) is stored at room temperature for 15 minutes, and then concentrated to dryness in vacuo to yield Nα -(2-acetylthiomethyl-5-aminopentanoyl)-L-arginine trifluoroacetate.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04129571uspto-grants-1978_12