Reaktion #941206

Reaktionsgleichung

6-Acetylamino-2-(N,N-dimethylamino)methyltetralin hydrochloride

hydrochloric acid

sodium hydroxide

→

compound

Ausbeute 36.4%

6-Amino-2-(N,N-dimethylamino)methyltetralin

Ausbeute 36.4%

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture was heated
2. 2
   Temperaturunder reflux for 90 minutes
3. 3
   ExtraktionThen, this was extracted with ethyl acetate
4. 4
   WaschenThe organic layer was washed with water
5. 5
   Trocknena saturated aqueous sodium chloride solution, then dried
6. 6
   Einengenconcentrated
7. 7
   SonstigeThe residue was purified by alumina column chromatography (eluent:ethyl acetate/hexane=1/1)

Vorschrift

6-Acetylamino-2-(N,N-dimethylamino)methyltetralin hydrochloride (0.879 g; obtained in Reference Example 31) was added to 2 N hydrochloric acid. The reaction mixture was heated under reflux for 90 minutes, and then an aqueous solution of 1 N sodium hydroxide was added thereto to thereby make the resulting mixture have pH of 9. Then, this was extracted with ethyl acetate. The organic layer was washed with water and a saturated aqueous sodium chloride solution, then dried, and concentrated. The residue was purified by alumina column chromatography (eluent:ethyl acetate/hexane=1/1) to obtain the entitled compound (0.231 g).

Quelle