Reaktion #94097

Reaktionsgleichung

4-(4-methylphenethyloxy)phenyl isocyanate

N,O-dimethylhydroxylamine

→

N'-[4-(4-methylphenethyloxy)phenyl]-N-methoxy-N-methylurea

Ausbeute 108.4%

Lösungsmittel

benzene

benzene

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONAfter the addition
2. 2
   SonstigeThereafter, the solvent is removed under reduced pressure
3. 3
   Sonstigethe residue is recrystallized from ethanol

Vorschrift

Into a solution of 5.5 g of 4-(4-methylphenethyloxy)phenyl isocyanate in 100 ml of benzene, a solution of 2 g of N,O-dimethylhydroxylamine in 50 ml of benzene is added dropwise at 20° to 30° C. After the addition is finished, the reaction mixture is continuously stirred at the same temperature for an additional 30 minutes. Thereafter, the solvent is removed under reduced pressure, and the residue is recrystallized from ethanol to obtain 7.4 g of N'-[4-(4-methylphenethyloxy)phenyl]-N-methoxy-N-methylurea as white needles, M.P. 82°-83° C.

Quelle