Reaktion #94080

Reaktionsgleichung

diethyl ketone

isopropanol

sodium hydroxide

β-hydroxybutyraldehyde

diethyl ketone

→

2,5,6-trimethyl-2-cyclohexen-1-one

Ausbeute 47.1%

Lösungsmittel

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturunder reflux
2. 2
   workup.WAITThe whole is boiled for another hour
3. 3
   Temperaturunder reflux
4. 4
   Sonstigethe aqueous phase is separated

Vorschrift

A mixture of 88 g of β-hydroxybutyraldehyde and 150 g of diethyl ketone is added dropwise in the course of one hour to a mixture of 250 g of diethyl ketone, 80 g of isopropanol and 5 g of sodium hydroxide powder which is boiling under reflux. The whole is boiled for another hour under reflux. Neutralization is effected with glacial acetic acid and the aqueous phase is separated. The organic layer is fractionated. 65 g of 2,5,6-trimethyl-2-cyclohexen-1-one having a boiling point of 74° to 76° C. at 12 mm Hg is obtained. The yield is 47% with reference to β-hydroxybutyraldehyde.

Quelle