Reaktion #94069

ord-85d034246f1042d1bf177df5576f2f9e

Reaktionsgleichung

COC(=O)CC(CSC(C)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O
Nα -[3-(acetylthio)-2-(methoxycarbonylmethyl)propanoyl]-L-arginine
COC(=O)CC(CSC(C)=O)C(=O)N1CCC[C@H]1C(=O)O
1-[3-(acetylthio)-2-(methoxycarbonylmethyl)propanoyl]-L-proline
→
N=C(N)NCCC[C@H](NC(=O)C(CS)CC(N)=O)C(=O)O
Nα -[3-mercapto-2-(carbamoylmethyl)propanoyl]-L-arginine

Edukte

COC(=O)CC(CSC(C)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O
Nα -[3-(acetylthio)-2-(methoxycarbonylmethyl)propanoyl]-L-arginine
COC(=O)CC(CSC(C)=O)C(=O)N1CCC[C@H]1C(=O)O
1-[3-(acetylthio)-2-(methoxycarbonylmethyl)propanoyl]-L-proline

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigeisolating the product with Dowex 50 resin

Vorschrift

By substituting Nα -[3-(acetylthio)-2-(methoxycarbonylmethyl)propanoyl]-L-arginine for the 1-[3-(acetylthio)-2-(methoxycarbonylmethyl)propanoyl]-L-proline in the procedure of Example 6A, and then isolating the product with Dowex 50 resin as described in the procedure of Example 17, Nα -[3-mercapto-2-(carbamoylmethyl)propanoyl]-L-arginine is obtained.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04128721uspto-grants-1978_12