Reaktion #93828

Reaktionsgleichung

Diethyl benzyloxymalonate

potassium hydroxide

→

benzyloxymalonic acid

Ausbeute 68.1%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas obtained
2. 2
   workup.STIRRINGstirring
3. 3
   workup.STIRRINGStirring
4. 4
   workup.WAITwas thereafter conducted under an atmosphere of argon at room temperature for about 16 hours
5. 5
   FiltrationThe product was filtered
6. 6
   Waschenwashed with ethanol, and diethyl ether
7. 7
   Sonstigedried under vacuum

Vorschrift

Diethyl benzyloxymalonate (6.0 g., 22.6 mmoles) was added to an ice cold solution of potassium hydroxide (2.66 g., 47.5 mmoles) in absolute ethanol. The mixture was stirred until a homogenous mixture was obtained and stirring continued for an additional 30 minutes in a cold environment. Stirring was thereafter conducted under an atmosphere of argon at room temperature for about 16 hours. The product was filtered, washed with ethanol, and diethyl ether and then dried under vacuum to yield the dipotassium salt of benzyloxymalonic acid (4.4 g., 15.4 mmoles, 68% yield).

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