Reaktion #93817

Reaktionsgleichung

2-chloro-α-phenyl-3-pyridinemetanol

acetyl chloride

trifluoroacetic acid

→

2-chloro-α-phenyl-3-pyridinemethanol acetate

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeat room temperature
2. 2
   SonstigeThe reaction liquid
3. 3
   Sonstigethe solid formed
4. 4
   Filtrationis filtered
5. 5
   Waschenwashed
6. 6
   Sonstigedried
7. 7
   Sonstigecrystallised from cyclohexane

Vorschrift

A mixture of 4.39 g 2-chloro-α-phenyl-3-pyridinemetanol (see Ex. 20), 3.14 g acetyl chloride and 8 ml trifluoroacetic acid is stirred for 1 hr. at room temperature. The reaction liquid is added dropwise to water, and the solid formed is filtered, washed, dried and crystallised from cyclohexane. Yield: 4.46 g title product, m.p. 100°-2° C.; Cl 13.82 (13.55).

Quelle