Reaktion #93814

Reaktionsgleichung

lithium aluminium hydride

3-benzoyl-2-chloropyridine

→

product

Ausbeute 42.1%

2-chloro-α-phenyl-3-pyridinemethanol

Ausbeute 42.1%

Lösungsmittel

pyridine

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.DISTILLATIONat room temperature, the solvent is distilled in vacuo
2. 2
   workup.ADDITIONthe residue is added to 5% aqueous HCl
3. 3
   Extraktionextracted with ether

Vorschrift

2.4 g lithium aluminium hydride is added very slowly to 10.6 g 3-benzoyl-2-chloropyridine in 100 ml anhydrous pyridine. After stirring for 2 hrs. at room temperature, the solvent is distilled in vacuo, the residue is added to 5% aqueous HCl and extracted with ether. Working as usual there is obtained 4.5 g of a product, identical with that obtained as in (a).

Quelle