Reaktion #93738
ord-88767fc2fc3d4a659afec7d93f59cd10
Reaktionsgleichung
Reaktionsbedingungen
Detaillierte Bedingungen
See reaction.notes.procedure_details.
Vorschrift
The 3-cyano-5-fluorophenacyl bromide from the above reaction is then dispersed in alcohol, preferably methanol, and reduced with sodium borohydride or sodium cyanoborohydride, or other reducing agents, such as hydrogen and a catalyst, e.g., platinum, palladium, or the like. The reaction yields 3-(2-bromo-1-hydroxyethyl)-5-fluorobenzonitrile which is readily converted to the formula I, 3-[2-(tert-butylamino)-1-hydroxyethyl]-5-fluorobenzonitrile or the 3-fluoro-5-[1-hydroxy-2-(isopropylamino)ethyl]-benzonitrile by reaction with t-butylamine or isopropylamine in the presence of ethanol.