Reaktion #93736

Reaktionsgleichung

tetrafluoroisophthalonitrile

sec-butanol

→

desired compound

Ausbeute 89.0%

2,4,5-Trifluoro-6-sec-butoxyisophthalonitrile

Ausbeute 89.0%

Lösungsmittel

acetonitrile

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationAfter the mixture was filtered
2. 2
   Einengenthe filtrate was concentrated in vacuo
3. 3
   workup.ADDITIONthe concentrated liquid was poured into 50 ml of water
4. 4
   ExtraktionThe mixture was extracted with carbon tetrachloride
5. 5
   WaschenAfter washing with water
6. 6
   Trocknenthe resultant mixture was dried with anhydrous magnesium sulfate
7. 7
   workup.DISTILLATIONthe solvent was then distilled off

Vorschrift

A 3.0 g amount of tetrafluoroisophthalonitrile and 1.26 g of 20 ml acetonitrile were dissolved in 20 ml of acetonitrile. A 1.66 g amount of sec-butanol was dropwise added to the mixture and the mixture was then stirred at room temperature for 24 hours. After the mixture was filtered, the filtrate was concentrated in vacuo and the concentrated liquid was poured into 50 ml of water. The mixture was extracted with carbon tetrachloride. After washing with water, the resultant mixture was dried with anhydrous magnesium sulfate and the solvent was then distilled off. Thus, 3.4 g (89% yield) of the desired compound No. 48 was obtained.

Quelle