Reaktion #93726

Reaktionsgleichung

potassium carbonate

methyl iodide

3-phenyl-5-chlorooxindole

→

3-Methyl-3-phenyl-5-chlorooxindole

Lösungsmittel

water

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenconcentrated
2. 2
   workup.ADDITIONwater was added to the residue, which
3. 3
   Extraktionwas extracted with ethyl acetate
4. 4
   Trocknenthe extract was dried over magnesium sulfate
5. 5
   Sonstigethe solvent was removed
6. 6
   SonstigeThe residue was recrystallized from ethanol

Vorschrift

10 g of 3-phenyl-5-chlorooxindole were dissolved in 100 ml of acetone and 20 ml of water, 2.9 g of potassium carbonate and 2.9 ml of methyl iodide were added and the mixture was warmed at 50° C. for 3 hours and concentrated; water was added to the residue, which was extracted with ethyl acetate, and the extract was dried over magnesium sulfate, and the solvent was removed. The residue was recrystallized from ethanol. Melting point 180°-181° C.

Quelle