Reaktion #93698

Reaktionsgleichung

n-octylamine

hydroquinone

acrylic acid

NaOH

→

N-n-octyl-β-alanine

Ausbeute 78.0%

Lösungsmittel

methanol

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added dropwise
2. 2
   Temperaturwhile cooling with ice
3. 3
   workup.ADDITIONAfter addition
4. 4
   Temperaturthe mixture was refluxed
5. 5
   Temperaturwhile heating for 4 hours
6. 6
   Filtrationfiltration
7. 7
   Sonstigedrying

Vorschrift

To a mixture of n-octylamine (516 g, 4.0 mols), hydroquinone (200 mg) and methanol (400 ml), acrylic acid (144 g, 2.0 mols) was added dropwise with stirring while cooling with ice. After addition, the mixture was refluxed while heating for 4 hours. After cooled to room temperature, NaOH (80 g, 2.0 mols) was added. The reaction mixture was despersed in 6 liters of acetone, and filtration and drying were carried out to obtain the Na salt of N-n-octyl-β-alanine as white crystals having a melting point (dec.) of 242° C. (349 g Yield: 78%).

Quelle