Reaktion #93538

Reaktionsgleichung

pyridine

α-mercaptomethyl-β-phenyl-γ-butyrolactone

p-n-butylbenzoyl chloride

→

title compound

Ausbeute 79.1%

α-(p-n-butylbenzoylthiomethyl)-β-phenyl-γ-butyrolactone

Ausbeute 79.1%

Lösungsmittel

ethyl ether

ethyl ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter completion of the reaction
2. 2
   Waschenwashed with 10% hydrochloric acid, 10% aqueous sodium hydrogen carbonate
3. 3
   Trocknendried over magnesium sulfate
4. 4
   workup.DISTILLATIONthe solvent was distilled off
5. 5
   SonstigeThe crude product thus obtained
6. 6
   Sonstigewas purified by a silica gel column chromatography

Vorschrift

To a solution of 1.5 g of α-mercaptomethyl-β-phenyl-γ-butyrolactone in 30 ml of ethyl ether were added at room temperature 4.3 g of p-n-butylbenzoyl chloride and then 1.9 ml of pyridine. The mixture was kept at room temperature for 2.5 hours. After completion of the reaction, the reaction mixture was diluted with 100 ml of ethyl ether, washed with 10% hydrochloric acid, 10% aqueous sodium hydrogen carbonate and then satureated saline, dried over magnesium sulfate and the solvent was distilled off. The crude product thus obtained was purified by a silica gel column chromatography to give 2.1 g (yield 79%) of the title compound.

Quelle