Reaktion #9352

Reaktionsgleichung

ether

2,6-diallyl-4-benzyloxyphenol

methyl α-bromo-4-chlorobenzeneacetate

Cs2CO3

→

methyl α-(2,6-diallyl-4-hydroxyphenoxy)-4-chlorobenzeneacetate

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with water and brine
2. 2
   Trocknendried over MgSO4
3. 3
   Filtrationfiltered
4. 4
   Einengenconcentrated in vac
5. 5
   SonstigePurification by chromatography (SiO2, EtOAc/Hexanes 1:20)

Vorschrift

To a solution of 2,6-diallyl-4-benzyloxyphenol (200 mg, 1.0 eq) in DMF (8 mL) were added methyl α-bromo-4-chlorobenzeneacetate (190 mg, 1.0 eq) and Cs2CO3 (285 mg, 1.2 eq). The reaction mixture was stirred at room temperature for 15 h, poured into ether, washed with water and brine, dried over MgSO4, filtered, and concentrated in vac. Purification by chromatography (SiO2, EtOAc/Hexanes 1:20) afforded the desired methyl α-(2,6-diallyl-4-hydroxyphenoxy)-4-chlorobenzeneacetate.

Quelle