Reaktion #9351

Reaktionsgleichung

4-benzyloxyphenol

allylbromide

K2CO3

acetone

→

desired product

2,6-diallyl-4-benzyloxyphenol

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture was refluxed overnight
2. 2
   Sonstigethe insoluble materials were removed by filtration
3. 3
   EinengenThe filtrate was concentrated in vac
4. 4
   SonstigeThe residue was partitioned between ethyl ether (500 mL) and 2N aqueous NaOH (200 mL)
5. 5
   WaschenThe organic layer was washed with water and brine
6. 6
   Trocknendried over anhydrous MgSO4
7. 7
   Filtrationfiltered
8. 8
   Einengenconcentrated in vac

Vorschrift

To a solution of starting 4-benzyloxyphenol (20 g) in acetone (800 mL) were added allylbromide (50 mL) and K2CO3 (60 g). The reaction mixture was refluxed overnight. After cooling to the room temperature, the insoluble materials were removed by filtration. The filtrate was concentrated in vac. The residue was partitioned between ethyl ether (500 mL) and 2N aqueous NaOH (200 mL). The organic layer was washed with water and brine, dried over anhydrous MgSO4, filtered, and concentrated in vac. to give the desired product.

Quelle