Reaktion #93508

Reaktionsgleichung

γ-chloro-p-fluorobutyrophenone

KOH

→

title compound

Cyclopropyl-4-fluorophenylmethanone

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextract with 3×30 ml of methylene chloride
2. 2
   WaschenWash the methylene chloride
3. 3
   Trocknendry over magnesium sulfate
4. 4
   Sonstigeevaporate off the solvent

Vorschrift

Add 20.0 g (0.10 mole) γ-chloro-p-fluorobutyrophenone dropwise to a methanolic KOH solution (prepared from 9.8 g of 86% KOH pellets and 60 ml of methanol). Stir the mixture at room temperature for 40 minutes and pour into 100 ml of water and then extract with 3×30 ml of methylene chloride. Wash the methylene chloride extracts with 3×40 ml of water, dry over magnesium sulfate and evaporate off the solvent to provide the title compound.

Quelle