Reaktion #935072

ord-f56ae91430084af6a4ca4772d6a34cae

Reaktionsgleichung

COC(=O)c1ncoc1Cc1ccccc1
Methyl 5-benzyl-4-oxazolecarboxylate
[Al+3].[H-].[H-].[H-].[H-].[Li+]
lithium aluminium hydride
→
OCc1ncoc1Cc1ccccc1
5-benzyl-4-hydroxymethyloxazole

Edukte

COC(=O)c1ncoc1Cc1ccccc1
Methyl 5-benzyl-4-oxazolecarboxylate
[Al+3].[H-].[H-].[H-].[H-].[Li+]
lithium aluminium hydride

Reagenzien

Keine

Lösungsmittel

C1CCOC1
tetrahydrofuran

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Methyl 5-benzyl-4-oxazolecarboxylate is reduced with lithium aluminium hydride in tetrahydrofuran to give 5-benzyl-4-hydroxymethyloxazole, which on reaction with thionyl chloride is converted to 5-benzyl-4-chloromethyloxazole.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04293697uspto-grants-1981_10