Reaktion #93500

Reaktionsgleichung

1-(2-cyclohexyl-4-quinolyl)-3-(4-piperidyl)-1-propanone monohydrochloride

sodium borohydride

sodium hydroxide

sodium methylate

sulfate

→

1-(2-cyclohexyl-4-quinolyl)-3-(4-piperidyl)-1-propanol

Ausbeute 28.0%

Lösungsmittel

ethanol

Reaktionsbedingungen

Vorschrift

The operation was as in Example 5, starting from 5.1 g of 1-(2-cyclohexyl-4-quinolyl)-3-(4-piperidyl)-1-propanone monohydrochloride, 1.3 ml of a 10N aqueous solution of sodium hydroxide (instead of sodium methylate) and 0.53 g of sodium borohydride in 100 ml of ethanol. 1.3 g of 1-(2-cyclohexyl-4-quinolyl)-3-(4-piperidyl)-1-propanol (racemic) were finally obtained in the form of the sulfate melting at 260° C.

Quelle