Reaktion #9349

Reaktionsgleichung

CF3CH2SO2Cl

NH4OH

→

CF3CH2SO2NH2

Lösungsmittel

water

CH2Cl2

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted three times with CH2Cl2
2. 2
   TrocknenThe combined organic layers were dried with Na2SO4
3. 3
   Einengenconcentrated
4. 4
   SonstigeThe sulfonamide was used without further purification

Vorschrift

The CF3CH2SO2NH2 was prepared by cooling a solution of commercially available CF3CH2SO2Cl (0.6 ml, 1 eq) in CH2Cl2 to 0° C. NH4OH (0.75 ml, 14.8 N, 2 eq) was then added dropwise. The mixture was allowed to warm to room temperature overnight. The reaction was diluted with water and extracted three times with CH2Cl2. The combined organic layers were dried with Na2SO4 and concentrated. The sulfonamide was used without further purification.

Quelle