Reaktion #93469

Reaktionsgleichung

2-Chloropropionic acid

benzyl alcohol

ether

Sodium

benzyl alcohol

sodium

→

2-benzyloxypropionic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe resulting mixture heated on additional 3 hours
2. 2
   EinengenConcentration in vacuo

Vorschrift

An alternate method for the preparation of ether compounds corresponding to Formula I (R=alkyl, phenylalkyl) follows. Sodium metal (about 12 g) was added cautiously to a stirred cold (ice bath) portion (250 mL) of benzyl alcohol. After most of the sodium metal had dissolved, the reaction was heated to 150° C. 2-Chloropropionic acid (27.2 g, 0.25 mole) was added dropwise in 35 mL of benzyl alcohol and the resulting mixture heated on additional 3 hours. Concentration in vacuo gave crude 2-benzyloxypropionic acid which was used without further purification.

Quelle